Use of sulfur hexafluoride and a three-dimensional sampling grid for evaluation of inhalation chamber performance.

Knowledge of the distribution of a toxic agent, for example, hydrogen sulfide, within an exposure chamber is essential for satisfactory inhalation toxicology studies. The use of a three-dimensional sampling grid is described for sampling inhalation chamber atmospheres containing various concentrations of sulfur hexafluoride gas as a substitute for the more toxic hydrogen sulfide.