Vidaña B, Floyd T, Brena C, Lyle R, Carson A, Hamilton C M, Wessels M
Pathology Department, Animal and Plant Health Agency (APHA)-Weybridge, Addlestone, UK.
Pathology Department, Animal and Plant Health Agency (APHA)-Weybridge, Addlestone, UK.
J Comp Pathol. 2020 Jan;174:58-62. doi: 10.1016/j.jcpa.2019.10.194. Epub 2019 Dec 4.
A 1.5-year-old ewe was presented with neurological signs that had been observed from about 2 days prior to death. There had been no clinical response to anti-inflammatory and antibiotic treatment. Histopathological examination of the brain revealed a severe and widespread eosinophilic meningoencephalomyelitis of unknown aetiology. Defining histological features included diffuse angiocentric eosinophilic infiltrates in the neuroparenchyma and meninges, neuronal necrosis, astrocytosis, neuropil vacuolation and occasional glial scars. Differential diagnostics for eosinophilic meningoencephalitis were taken into account and investigated by means of special stains, immunohistochemistry, bacteriology and polymerase chain reaction. No pathological changes or ancillary tests were supportive or revealed a specific aetiology for the condition and therefore it was considered idiopathic. Idiopathic meningoencephalitis is a rare disease, mainly described in man and rarely in dogs, with no apparent aetiological cause or potential breed predisposition. To our knowledge this is the first case of idiopathic eosinophilic meningoencephalitis in a sheep and provides a histopathological guideline for prospective comparative pathology studies.
一只1.5岁的母羊出现了从死亡前约2天开始观察到的神经症状。抗炎和抗生素治疗均无临床反应。对大脑进行组织病理学检查发现了一种病因不明的严重广泛性嗜酸性脑膜脑脊髓炎。明确的组织学特征包括神经实质和脑膜中弥漫性血管中心性嗜酸性浸润、神经元坏死、星形胶质细胞增生、神经纤维网空泡化以及偶尔的胶质瘢痕。考虑了嗜酸性脑膜脑脊髓炎的鉴别诊断，并通过特殊染色、免疫组织化学、细菌学和聚合酶链反应进行了研究。没有病理变化或辅助检查支持或揭示该病症的特定病因，因此认为是特发性的。特发性脑膜脑脊髓炎是一种罕见疾病，主要在人类中描述，在犬类中很少见，没有明显的病因或潜在的品种易感性。据我们所知，这是绵羊中首例特发性嗜酸性脑膜脑脊髓炎病例，为前瞻性比较病理学研究提供了组织病理学指导方针。
