Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Maastricht, the Netherlands.
Université de Strasbourg, INSERM, Etablissement Français du Sang (EFS)-Grand Est, BPPS UMR_S 1255, Fédération de Médecine Translationnelle de Strasbourg (FMTS).
Platelets. 2020 May 18;31(4):439-446. doi: 10.1080/09537104.2019.1708884. Epub 2020 Jan 19.
In spite of current treatment strategies, myocardial infarction and stroke are still major causes of death worldwide. These events are triggered by damage of an atherosclerotic plaque, resulting in occlusive thrombus formation. Mouse studies have significantly contributed to our understanding of the mechanisms of atherogenesis and of thrombosis following plaque injury, but the extent to which the mouse serves as an accurate model of human disease is open to discussion. In this review, we provide a detailed overview and comparison of the described mouse models for atherothrombosis including their (dis)advantages. Herein guidance is provided on how to select a suitable atherothrombosis model for research questions primarily relevant to the field of thrombosis.
尽管目前有治疗策略，心肌梗死和中风仍然是全球主要的死亡原因。这些事件是由动脉粥样硬化斑块的损伤引发的，导致闭塞性血栓形成。小鼠研究极大地促进了我们对动脉粥样硬化形成和斑块损伤后血栓形成机制的理解，但小鼠作为人类疾病准确模型的程度仍存在争议。在这篇综述中，我们详细概述并比较了描述性的动脉粥样血栓形成小鼠模型，包括它们的（优缺点）。本文提供了如何为主要与血栓形成领域相关的研究问题选择合适的动脉粥样血栓形成模型的指导。
