Merino-Gutierrez Virginia, Feo-Bernabé Luis, Clemente-Vicario Francisco, Puig Jordi
From Ars Veterinary Hospital, Barcelona, Spain.
J Am Anim Hosp Assoc. 2020 Mar/Apr;56(2):e56203. doi: 10.5326/JAAHA-MS-6953. Epub 2020 Jan 21.
A 12 yr old intact female Siberian husky was referred with a 2 wk history of progressive weakness, paraparesis, anorexia, and panting. A 4 cm diameter grade 3 mammary solid carcinoma involving the fifth right mammary gland had been removed 2 days prior to the current visit. While hospitalized, the dog was diagnosed with Addison's disease based on electrolyte disturbances and low serum cortisol levels following adrenocorticotropic hormone stimulation test. An abdominal ultrasound revealed adrenal glands at the upper limit of normal size. Despite treatment, the dog deteriorated and died 4 days after presentation. A postmortem examination revealed a neoplastic infiltrate of epithelial malignant cells in both adrenal glands, popliteal lymph nodes, vertebral bodies, and paralumbar musculature, compatible with metastasis from mammary carcinoma. To our knowledge, this is the first reported case of Addison's disease secondary to metastatic mammary carcinoma in a dog.
一只12岁未绝育的雌性西伯利亚哈士奇因进行性虚弱、截瘫、厌食和气喘2周病史前来就诊。此次就诊前两天，已切除一个直径4厘米、累及右侧第五乳腺的3级乳腺实体癌。住院期间，根据促肾上腺皮质激素刺激试验后的电解质紊乱和低血清皮质醇水平，该犬被诊断为艾迪生病。腹部超声显示肾上腺大小在正常上限。尽管进行了治疗，但该犬在就诊后4天病情恶化死亡。尸检发现双侧肾上腺、腘淋巴结、椎体和腰旁肌肉组织有上皮性恶性细胞的肿瘤浸润，符合乳腺癌转移。据我们所知，这是首例报道的犬转移性乳腺癌继发艾迪生病的病例。
