Maccabitech, Maccabi Healthcare Services.
Pediatric Gastroenterology Unit, Dana-Dwek Children's Hospital, Tel-Aviv Sourasky Medical Center.
J Pediatr Gastroenterol Nutr. 2020 Apr;70(4):478-481. doi: 10.1097/MPG.0000000000002624.
Little is known about the effect of prematurity on later development of celiac disease (CD). We conducted a retrospective analysis of real-world data examining the association between very low birth weight (VLBW) prematurity and later development of CD autoimmunity (CDA) in 3580 infants born between years 2000 and 2012 and their matched controls. At a median of 12 years, VLBW prematurity was negatively associated with later development of CDA with a cumulative prevalence of 5.9 per 1000 versus 10.3 per 1000 (P = 0.02), though more former VLBW premature infants were ever tested for CDA (48.5% vs 37.4%, P < 0.001). The odds ratio for developing CDA among children born preterm at VLBW was 0.57 (95% confidence interval (CI) 0.35-0.92) as compared with matched controls. There was no difference in clinical characteristics of CDA between both groups. In conclusion, VLBW preterm infants present a decreased risk for the development of CDA during childhood and adolescence.
关于早产对乳糜泻（CD）后期发展的影响知之甚少。我们对 2000 年至 2012 年间出生的 3580 名婴儿及其匹配对照的真实数据进行了回顾性分析，以检查极低出生体重（VLBW）早产儿与后期自身免疫性乳糜泻（CDA）发展之间的关系。在中位数为 12 年时，VLBW 早产儿与 CDA 后期发展呈负相关，累积患病率为 5.9/1000 比 10.3/1000（P=0.02），尽管更多的前 VLBW 早产儿接受了 CDA 检测（48.5%比 37.4%，P<0.001）。与匹配对照相比，VLBW 早产儿出生时发生 CDA 的比值比为 0.57（95%置信区间（CI）0.35-0.92）。两组 CDA 的临床特征无差异。总之，VLBW 早产儿在儿童和青少年时期发生 CDA 的风险降低。
