Heger W, Klug S, Schmahl H J, Nau H, Merker H J, Neubert D
Institut für Toxikologie und Embryopharmakologie, Freie Universität Berlin.
Arch Toxicol. 1988;62(2-3):205-8. doi: 10.1007/BF00570141.
The teratogenic potencies of the enantiomers of 2-(2,6-dioxopiperidine-3-yl)-phthalimidine ( = EM 12), a teratogenic thalidomide analogue, were investigated in Callithrix jacchus, a primate very sensitive to the teratogenic action of this thalidomide analogue. The results indicate that the S-(-)-form of EM 12 is clearly more teratogenic than the R-(+)-form. The interpretation of the studies designed to evaluate stereo-selective differences in the teratogenicity of the enantiomers becomes difficult, since both enantiomers racemise in vivo with appreciable rates (Schmahl et al. 1988a, b). Therefore, it cannot be concluded as yet that the R-(+)-form lacks all teratogenic potential.
2-(2,6-二氧代哌啶-3-基)邻苯二甲酰亚胺（=EM 12）是一种致畸性沙利度胺类似物，在对这种沙利度胺类似物的致畸作用非常敏感的灵长类动物狨猴中研究了其对映体的致畸效力。结果表明，EM 12的S-(-)-形式明显比R-(+)-形式更具致畸性。由于两种对映体在体内都以相当的速率外消旋化（施马尔等人，1988a，b），因此旨在评估对映体致畸性中立体选择性差异的研究的解释变得困难。因此，目前还不能得出R-(+)-形式没有任何致畸潜力的结论。
