仿生全合成 Sanctis A-B 并进行结构修正。
Biomimetic Total Syntheses of Sanctis A-B with Structure Revision.
机构信息
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650 , China.
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology, Guangdong Academy of Sciences , Guangzhou 510070 , China.
出版信息
Org Lett. 2020 Feb 7;22(3):934-938. doi: 10.1021/acs.orglett.9b04486. Epub 2020 Jan 21.
The first concise total syntheses of sanctis A and B were reported, and it enabled revision of the structure of sanctis B through single-crystal X-ray diffraction. The established synthetic approach mainly mimics a biosynthetic olefin isomerization/hemiacetalization/dehydration/[3 + 3]-type cycloaddition cascade sequence, offering a viable synthetic methodology to efficiently access sanctis A-B and their analogues.
首次简洁地全合成了 sanctis A 和 B，并通过单晶 X 射线衍射修正了 sanctis B 的结构。所建立的合成方法主要模拟了生物合成中的烯烃异构化/半缩醛化/脱水/[3 + 3]-型环加成级联序列，为高效获得 sanctis A-B 及其类似物提供了可行的合成方法。
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