Department of Neurology, First Affiliated Hospital of Kangda College, Nanjing Medical University, Lianyungang, China.
Department of Neurology, Qingdao Municipal Hospital, Qingdao Clinical Medical College, Nanjing Medical University, Qingdao, China.
Aging (Albany NY). 2020 Jan 21;12(2):1322-1331. doi: 10.18632/aging.102685.
The prevalence of intracranial arterial stenosis (IAS) as well as antinuclear antibody (ANA) positivity was found to be higher in Asians than that in the Western population. To investigate the relation of ANAs with IAS in patients with acute ischemic cerebrovascular disease, we enrolled 2492 patients with acute ischemic stroke or transient ischemic attack into the study. All the patients were categorized into 3 groups according to the IAS burden. Multinomial logistic regression analyses were used in statistical analysis. The positive rate of ANAs in the IAS ≥ 2 group was higher than that in the single IAS group and the no IAS group (p<0.001). The adjusted odds ratio (OR) for IAS ≥ 2 in ANAs-positive patients was 3.737 (95%CI=2.676-5.220, p<0.001) compared with the ANAs-negative patients. ANAs were associated with multiple IAS rather than single IAS in both male and female subgroups. Besides, ANAs were significantly associated with single and multiple IAS in individuals ≤ 60 years. However, ANAs were only associated with two or more IAS in two age groups (between 61 to 75 years and >75 years old). In summary, ANAs are associated with IAS in patients with acute ischemic cerebrovascular disease.
颅内动脉狭窄（IAS）的患病率以及抗核抗体（ANA）阳性率在亚洲人群中均高于西方人群。为了研究急性缺血性脑血管病患者的 ANA 与 IAS 的关系，我们纳入了 2492 例急性缺血性卒中和短暂性脑缺血发作患者进行研究。所有患者根据 IAS 负担分为 3 组。统计分析采用多项逻辑回归分析。在 IAS≥2 组中 ANA 的阳性率高于单一 IAS 组和无 IAS 组（p<0.001）。与 ANA 阴性患者相比，ANA 阳性患者 IAS≥2 的调整优势比（OR）为 3.737（95%CI=2.676-5.220，p<0.001）。在男性和女性亚组中，ANA 与多发 IAS 而非单发 IAS 相关。此外，在≤60 岁的个体中，ANA 与单发和多发 IAS 均显著相关。然而，ANA 仅与两个或更多 IAS 相关，分别在 61 至 75 岁和>75 岁两个年龄组中。总之，ANA 与急性缺血性脑血管病患者的 IAS 相关。
