Department of Neurology, Second Affiliated Hospital of Fujian Medical University, Zhongshan North Road 34, Quanzhou, 362000, Fujan, China.
Department of Neurology, Jinjiang Municipal Hospital, Jinjiang, 362200, Fujian, China.
Neurol Sci. 2019 May;40(5):957-961. doi: 10.1007/s10072-019-03737-2. Epub 2019 Jan 31.
To determine whether uric acid (UA) and intracranial and extracranial atherosclerosis stenosis of elderly patients suffering from ischaemic stroke are inter-related.
Elderly patients with ischaemic stroke underwent computed tomography angiography (CTA) were enrolled between October 2015 and December 2017. We collected clinical assessment, image data, and laboratory tests, and divided patients into four groups: (1) intracranial stenosis atherosclerosis (ICAS) group, (2) combined intracranial and extracranial atherosclerosis stenosis (COAS) group, (3) extracranial carotid stenosis atherosclerosis (ECAS) group, and (4) non-cerebral stenosis atherosclerosis (NCAS) group. We used univariate and multiple logistic regression analyses to explore potential predictors.
We included 408 patients in this study, then divided them into elder group (n = 196) and young- and middle-aged group (n = 212). In old stroke patients, 72 cases (36.73%) were classified as the ICAS group, 45 cases (22.96%) as the COAS group, 21 cases (10.71%) as the ECAS group, and 58 cases (29.59%) as the NCAS group. The level of UA was comparatively higher (p = 0.033) in ICAS than in NCAS. Compared with the group which had only one stenosis artery, UA was substantially increased in patients with more than one stenosis intracranial artery (p < 0.001). With a multivariable analysis, UA was an independent predictor for intracranial stenosis of elderly patients (OR = 1.003, p = 0.042), but the relationship between extracranial artery stenosis and uric acid was negative.
Hyperuricaemia is a risk factor of intracranial artery stenosis rather than of ECAS in elderly patients with cerebral infarction.
为了确定老年缺血性脑卒中患者尿酸（UA）与颅内和颅外动脉粥样硬化狭窄是否相关。
2015 年 10 月至 2017 年 12 月，连续纳入接受计算机断层血管造影（CTA）检查的老年缺血性脑卒中患者。收集临床评估、影像学数据和实验室检查结果，并将患者分为四组：（1）颅内动脉狭窄粥样硬化（ICAS）组，（2）颅内和颅外动脉粥样硬化狭窄并存（COAS）组，（3）颅外颈动脉狭窄粥样硬化（ECAS）组，（4）非脑动脉狭窄粥样硬化（NCAS）组。采用单因素和多因素 logistic 回归分析探讨潜在的预测因素。
本研究共纳入 408 例患者，分为老年组（n = 196）和中青年组（n = 212）。在老年脑卒中患者中，72 例（36.73%）为 ICAS 组，45 例（22.96%）为 COAS 组，21 例（10.71%）为 ECAS 组，58 例（29.59%）为 NCAS 组。与 NCAS 组相比，ICAS 组 UA 水平显著升高（p = 0.033）。与仅存在一支狭窄血管的患者相比，UA 水平在颅内多支狭窄患者中显著升高（p < 0.001）。多因素分析显示，UA 是老年患者颅内狭窄的独立预测因素（OR = 1.003，p = 0.042），但与颅外动脉狭窄的关系为负相关。
高尿酸血症是老年脑梗死患者颅内动脉狭窄的危险因素，而不是颅外动脉狭窄的危险因素。
