抑郁与睡眠：治疗研究揭示了什么？HPA 轴是否是一个潜在的机制？
Depression and sleep: what has the treatment research revealed and could the HPA axis be a potential mechanism?
机构信息
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA; Lauren Asarnow is now at the Department of Psychiatry, University of California, San Francisco, CA, USA.
出版信息
Curr Opin Psychol. 2020 Aug;34:112-116. doi: 10.1016/j.copsyc.2019.12.002. Epub 2019 Dec 20.
Abstract
Research indicates that insomnia improvement plays a critical role in depression symptom improvement. In line with the National Institute of Mental Health Experimental Therapeutics approach recent research focuses on identifying specific mechanisms; the present manuscript aims to review recent research on one potential mechanism, dysfunction in the HPA axis which is a shared biological substrate of both depression and insomnia. Over the past five years, research demonstrated a relationship between sleep disturbance and cortisol reactivity and recovery following a stressor. Meanwhile, research on the relationship between depression and HPA axis functioning is less consistent and is dependent on measurement of HPA axis. Experimental research that aims to determine a causal pathway between sleep, depression and HPA axis functioning is needed.
摘要
研究表明，失眠改善对抑郁症状改善起着关键作用。与国家心理健康研究所的实验治疗方法一致，最近的研究重点是确定特定的机制；本手稿旨在回顾近年来关于潜在机制的研究，即 HPA 轴功能障碍，这是抑郁和失眠的共同生物学基础。在过去的五年中，研究表明睡眠障碍与皮质醇反应和应激后恢复之间存在关系。同时，关于抑郁与 HPA 轴功能的关系的研究则不太一致，并且取决于 HPA 轴的测量。需要进行旨在确定睡眠、抑郁和 HPA 轴功能之间因果关系的实验研究。
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