Laboratory for Biologically Inspired Computing, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka 565-0874, Japan.
Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2052, Australia.
Phys Rev E. 2019 Dec;100(6-1):062407. doi: 10.1103/PhysRevE.100.062407.
While cooperativity in ligand-induced receptor dimerization has been linked with receptor-receptor couplings via minimal representations of physical observables, effects arising from higher-order oligomer, e.g., trimer and tetramer, formations of unobserved receptors have received less attention. Here we propose a dimerization model of ligand-induced receptors in multivalent form representing physical observables under basis vectors of various aggregated receptor states. Our simulations of multivalent models not only reject Wofsy-Goldstein parameter conditions for cooperativity, but show that higher-order oligomer formations can shift cooperativity from positive to negative.
虽然配体诱导的受体二聚体中的协同作用与通过物理可观测量的最小表示的受体-受体偶联有关，但来自更高阶寡聚体（例如三聚体和四聚体）形成的、未观察到的受体的影响受到的关注较少。在这里，我们提出了一种配体诱导的多价形式的受体二聚化模型，该模型代表了各种聚集受体状态的基向量下的物理可观测量。我们对多价模型的模拟不仅拒绝了 Wofsy-Goldstein 协变参数条件，而且表明高阶寡聚体的形成可以使协同作用从正变为负。
