Del Angel-Pablo Alma D, Juárez-Martín Ana Itzel, Pérez-Rubio Gloria, Ambrocio-Ortiz Enrique, López-Flores Luis A, Camarena Angel E, Falfán-Valencia Ramcés
HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Diagnostics (Basel). 2020 Jan 16;10(1):47. doi: 10.3390/diagnostics10010047.
Genetic variability defends us against pathogen-driven antigens; human leucocyte antigens (HLA) is the immunological system in charge of this work. The Mexican mestizo population arises mainly from the mixture of three founder populations; Amerindian, Spaniards, and a smaller proportion of the African population. We describe allele and haplotype frequencies of HLA class I (- and ) and class II (- and -), which were analyzed by PCR-SSP in Mexican mestizo from three urban populations of Mexico: Chihuahua-Chihuahua City ( = 88), Mexico City-Tlalpan ( = 330), and Veracruz-Xalapa ( = 84). The variability of the allele HLA class I and class II among the three regions of Mexico are in four alleles: (36.39%), (16.04%), (17.33%), and - (31.47%), these alleles have been previously described in some indigenous populations. We identified 5 haplotypes with a frequency >1%: , , , and . Also, the haplotype was identified in Tlalpan and Xalapa regions. Haplotype was found only in Tlalpan and Chihuahua. In the Xalapa region, the most frequent haplotype was . These alleles and haplotypes have been described in Amerindian populations. Our data are consistent with previous studies and contribute to the analysis of the variability in the Mexican population.
基因变异性保护我们抵御病原体驱动的抗原；人类白细胞抗原（HLA）是负责此项工作的免疫系统。墨西哥混血人群主要源自三个奠基人群体的混合；美洲印第安人、西班牙人以及较小比例的非洲人群体。我们描述了HLA I类（-和）和II类（-和-）的等位基因及单倍型频率，这些通过聚合酶链反应-序列特异性引物（PCR-SSP）在来自墨西哥三个城市人群的墨西哥混血儿中进行分析：奇瓦瓦州奇瓦瓦市（=88）、墨西哥城特拉尔潘（=330）和韦拉克鲁斯州哈拉帕（=84）。墨西哥三个地区之间HLA I类和II类等位基因的变异性存在于四个等位基因中：（36.39%）、（16.04%）、（17.33%）和-（31.47%），这些等位基因先前已在一些土著人群体中被描述。我们鉴定出频率>1%的5种单倍型：、、、和。此外，单倍型在特拉尔潘和哈拉帕地区被鉴定出来。单倍型仅在特拉尔潘和奇瓦瓦被发现。在哈拉帕地区，最常见的单倍型是。这些等位基因和单倍型已在美洲印第安人群体中被描述。我们的数据与先前的研究一致，并有助于对墨西哥人群体中的变异性进行分析。
