Department of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, and Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain.
Cells. 2020 Jan 16;9(1):228. doi: 10.3390/cells9010228.
CD38 is a multifunctional protein widely expressed in cells from the immune system and as a soluble form in biological fluids. CD38 expression is up-regulated by an array of inflammatory mediators, and it is frequently used as a cell activation marker. Studies in animal models indicate that CD38 functional expression confers protection against infection by several bacterial and parasitic pathogens. In addition, infectious complications are associated with anti-CD38 immunotherapy. Although CD38 displays receptor and enzymatic activities that contribute to the establishment of an effective immune response, recent work raises the possibility that CD38 might also enhance the immunosuppressive potential of regulatory leukocytes. This review integrates the current knowledge on the diversity of functions mediated by CD38 in the host defense to infection.
CD38 是一种多功能蛋白，广泛表达于免疫系统细胞，也以可溶性形式存在于生物体液中。CD38 的表达受一系列炎症介质的上调调控，常被用作细胞激活标志物。动物模型研究表明，CD38 的功能性表达可提供针对多种细菌和寄生虫病原体感染的保护。此外，感染并发症与抗 CD38 免疫疗法相关。尽管 CD38 具有促进有效免疫反应的受体和酶活性，但最近的研究提出了一种可能性，即 CD38 可能也增强了调节性白细胞的免疫抑制潜力。本综述整合了当前关于 CD38 在宿主抗感染防御中所介导的多种功能的知识。
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