Park Eun J, Appiah Michael G, Myint Phyoe K, Gaowa Arong, Kawamoto Eiji, Shimaoka Motomu
Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514- 8507, Japan.
Department of Emergency and Disaster Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Curr Pharm Des. 2019;25(42):4486-4495. doi: 10.2174/1381612825666191116125525.
Sepsis is the leading cause of death in medical intensive care units, and thus represents a serious healthcare problem worldwide. Sepsis is often caused by the aberrant host responses to infection, which induce dysregulated inflammation that leads to life-threatening multiple organ failures. Mediators such as proinflammatory cytokines that drive the sepsis pathogenesis have been extensively studied. Exosomes, biological lipid bilayer nanoparticles secreted via the endosomal pathway of cells, have recently emerged as important cargos that carry multiple mediators critical for the pathogenesis of sepsis-associated organ dysfunctions. Here we will review current knowledge on the exosomes in sepsis and relevant inflammatory tissue injuries.
脓毒症是医学重症监护病房中主要的死亡原因，因此是全球范围内一个严重的医疗保健问题。脓毒症通常由宿主对感染的异常反应引起，这种反应会引发失调的炎症，进而导致危及生命的多器官功能衰竭。驱动脓毒症发病机制的介质，如促炎细胞因子，已得到广泛研究。外泌体是通过细胞内体途径分泌的生物脂质双层纳米颗粒，最近已成为重要的载体，携带对脓毒症相关器官功能障碍发病机制至关重要的多种介质。在此，我们将综述目前关于脓毒症中外泌体及相关炎症组织损伤的知识。
