Nishikawa Hiroki, Takata Ryo, Enomoto Hirayuki, Yoh Kazunori, Iwata Yoshinori, Sakai Yoshiyuki, Kishino Kyohei, Shimono Yoshihiro, Ikeda Naoto, Takashima Tomoyuki, Aizawa Nobuhiro, Hasegawa Kunihiro, Ishii Noriko, Yuri Yukihisa, Nishimura Takashi, Iijima Hiroko, Nishiguchi Shuhei
Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
J Clin Med. 2020 Jan 17;9(1):255. doi: 10.3390/jcm9010255.
We sought to clarify the correlation between non-protein respiratory quotient (npRQ) in indirect calorimetry and serum zinc (Zn) level in chronic liver diseases (CLDs, = 586, 309 liver cirrhosis (LC) patients, median age = 63 years). Clinical parameters potentially linked to npRQ <0.85 (best cutoff point for the prognosis in LC patients) were also examined in receiver operating characteristic curve (ROC) analyses. The median npRQ was 0.86. The median serum Zn level was 64 μg/dL. The median npRQ in patients with non-LC, Child-Pugh A, Child-Pugh B and Child-Pugh C were 0.89, 0.85, 0.83 and 0.82 (overall < 0.0001)). The median serum Zn level in patients with npRQ <0.85 (58 μg/dL) was significantly lower than that in patients with npRQ ≥ 0.85 (68 μg/dL) ( < 0.0001). The correlation coefficient () between npRQ level and serum Zn level for all cases was 0.40 ( < 0.0001). Similar tendencies were observed in all subgroup analyses. The highest correlation coefficient between serum Zn level and npRQ was found in patients with Child-Pugh C ( = 22, = 0.69). In ROC analyses for npRQ <0.85, serum Zn level had the highest area under the ROC (AUC) among baseline laboratory parameters (AUC = 0.69). In conclusion, serum Zn level can be helpful for npRQ in patients with CLDs.
我们试图阐明间接测热法中无蛋白呼吸商（npRQ）与慢性肝病（CLD，n = 586，其中309例为肝硬化（LC）患者，中位年龄 = 63岁）患者血清锌（Zn）水平之间的相关性。在受试者工作特征曲线（ROC）分析中，还对可能与npRQ <0.85（LC患者预后的最佳截断点）相关的临床参数进行了研究。npRQ的中位数为0.86。血清锌水平的中位数为64μg/dL。非LC、Child-Pugh A级、Child-Pugh B级和Child-Pugh C级患者的npRQ中位数分别为0.89、0.85、0.83和0.82（总体P < 0.0001）。npRQ <0.85的患者血清锌水平中位数（58μg/dL）显著低于npRQ≥0.85的患者（68μg/dL）（P < 0.0001）。所有病例中npRQ水平与血清锌水平之间的相关系数（r）为0.40（P < 0.0001）。在所有亚组分析中均观察到类似趋势。血清锌水平与npRQ之间的相关系数在Child-Pugh C级患者中最高（n = 22，r = 0.69）。在npRQ <0.85的ROC分析中，血清锌水平在基线实验室参数中具有最高的ROC曲线下面积（AUC）（AUC = 0.69）。总之，血清锌水平对CLD患者的npRQ可能有帮助。
