药物-蛋白质相互作用。关于左旋咪唑在体外诱导的蛋白质-蛋白质相互作用。一种机制假说。
Drug-protein interactions. On the protein-protein interaction induced by levamisole in vitro. A mechanism hypothesis.
作者信息
Chicault M, Luu Duc C, Boucherle A
机构信息
Unité de Formation et de Recherche de Pharmacie, Université Joseph Fourier Grenoble, Meylan, France.
出版信息
Arzneimittelforschung. 1988 Oct;38(10):1387-9.
PMID:3196377
Abstract
In the present communication, a model is reported in order to explain the aggregation of albumin induced by levamisole in vitro. The hypothesis suggests that the process of polymerization of albumins may include ligand-protein interaction as a biochemical catalysis, and covalent protein-protein interactions by a mechanism of disulfide-sulfhydryl interchange by intramolecular or intermolecular reactions.
摘要
在本通讯中，报道了一个模型以解释左旋咪唑在体外诱导白蛋白聚集的现象。该假说认为，白蛋白的聚合过程可能包括作为生化催化的配体-蛋白质相互作用，以及通过分子内或分子间反应的二硫键-巯基交换机制形成的共价蛋白质-蛋白质相互作用。
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