Mastropasqua Rodolfo, D'Aloisio Rossella, De Nicola Chiara, Ferro Giada, Senatore Alfonso, Libertini Daniele, Di Marzio Guido, Di Nicola Marta, Di Martino Giuseppe, Di Antonio Luca, Toto Lisa
Institute of Ophthalmology, University of Modena and Reggio Emilia, Via Università, 4, 41121 Modena (MO), Italy.
Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, 66100 Chieti, Italy.
Diagnostics (Basel). 2020 Jan 19;10(1):50. doi: 10.3390/diagnostics10010050.
(1) Background: To evaluate superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC), perfusion density (PD), and vessel length density (VLD) in macular and near/mid periphery regions in patients with retinitis pigmentosa (RP) using widefield swept source optical coherence tomography angiography (WSS-OCTA). (2) Methods: Twelve RP patients (20 eyes) and 20 age-matched subjects (20 eyes) were imaged with the SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). Quantitative analysis was performed in the macular and peripheral regions. The main outcome measures were SCP, DCP, CC, PD, and VLD in central and peripheral areas. (3) Results: Mean visual acuity, central macular thickness, and microperimetry were significantly reduced in RP patients compared to normal subjects ( < 0.05). The perfusion density and VLD of SCP, DCP, and CC were significantly reduced in RP patients compared to normal controls both in the central and peripheral retina ( < 0.05). A significant direct correlation was found in RP patients between PD of the 1.5 mm central retina both in DCP and CC and microperimetry at 4° and 8°. (4) Conclusions: Widefield SS-OCTA shows an impairment of retinal and choroidal perfusion density and vessel length density in central and peripheral retina of RP patients. The reduction of flow features correlates with the macular function.
(1) 背景：使用超广角扫频光学相干断层扫描血管造影（WSS-OCTA）评估视网膜色素变性（RP）患者黄斑区以及近/中周边区域的浅表毛细血管丛（SCP）、深部毛细血管丛（DCP）、脉络膜毛细血管（CC）、灌注密度（PD）和血管长度密度（VLD）。(2) 方法：对12例RP患者（20只眼）和20名年龄匹配的受试者（20只眼）使用SS-OCTA系统（PLEX Elite 9000，卡尔蔡司医疗技术公司，美国加利福尼亚州都柏林）进行成像。在黄斑区和周边区域进行定量分析。主要观察指标为中心和周边区域的SCP、DCP、CC、PD和VLD。(3) 结果：与正常受试者相比，RP患者的平均视力、中心黄斑厚度和微视野检查结果显著降低（<0.05）。与正常对照组相比，RP患者视网膜中央和周边区域的SCP、DCP和CC的灌注密度和VLD均显著降低（<0.05）。在RP患者中，DCP和CC中1.5mm中央视网膜的PD与4°和8°的微视野检查结果之间存在显著的正相关。(4) 结论：超广角SS-OCTA显示RP患者视网膜中央和周边区域的视网膜和脉络膜灌注密度以及血管长度密度受损。血流特征的降低与黄斑功能相关。
