Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California.
Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Retina. 2019 Jun;39(6):1216-1224. doi: 10.1097/IAE.0000000000002123.
To report optical coherence tomography angiography (OCTA) values in healthy pediatric eyes and to identify factors that may modify these values.
In this prospective observational cross-sectional study, macular OCTA images were acquired from healthy pediatric patients. Main outcome measures were 1) foveal avascular zone (FAZ) area at the level of the superficial retinal capillary plexus (SCP); 2) SCP and deep retinal capillary plexus (DCP) perfusion density (based on the area of vessels); 3) SCP and DCP vessel density (based on a map with vessels of 1-pixel width); and 4) CC perfusion density. Multiple regression analysis was performed to assess the effect of age, sex, ethnicity, refraction, and foveal macular thickness (FMT) on OCTA parameters.
Seventy-seven eyes from 52 subjects (23 male and 29 female) were included in analysis. Mean age was 11.1 ± 3.3 years (range = 5.0-17.0 years). Twenty-nine (55.8%) subjects were white, 14 (27.0%) Hispanic, 8 (15.4%) Asian, and 1 (1.8%) African-American. Mean refraction was -0.1 ± 2.4 diopters (D) (range = -5.75 to +9.0 D). Mean FMT was 248.6 ± 18.6 μm. Larger FAZ area was significantly associated with older age (P = 0.014). Furthermore, larger FAZ area was associated with reduced FMT (P < 0.0001). Male sex was associated only with increased SCP perfusion density (P = 0.042). Increased CC perfusion density was associated with younger age (P = 0.022).
We report data for pediatric OCTA parameters in healthy subjects. Several variables influence the density of macular microvascular networks, and these factors should be considered in the OCTA study of pediatric eye disorders.
报告健康儿童眼的光学相干断层扫描血管造影（OCTA）值，并确定可能改变这些值的因素。
在这项前瞻性观察性横断面研究中，从健康的儿科患者中获取黄斑 OCTA 图像。主要观察指标为：1）浅层视网膜毛细血管丛（SCP）水平的中央凹无血管区（FAZ）面积；2）SCP 和深层视网膜毛细血管丛（DCP）灌注密度（基于血管面积）；3）SCP 和 DCP 血管密度（基于具有 1 个像素宽度的血管图）；4）CC 灌注密度。多元回归分析用于评估年龄、性别、种族、屈光不正和黄斑中心凹视网膜厚度（FMT）对 OCTA 参数的影响。
77 只眼（52 名患者，23 名男性和 29 名女性）纳入分析。平均年龄为 11.1±3.3 岁（范围=5.0-17.0 岁）。29 名（55.8%）受试者为白人，14 名（27.0%）为西班牙裔，8 名（15.4%）为亚洲人，1 名（1.8%）为非裔美国人。平均屈光度为-0.1±2.4 屈光度（D）（范围=-5.75 至+9.0 D）。平均 FMT 为 248.6±18.6μm。较大的 FAZ 面积与年龄较大显著相关（P=0.014）。此外，较大的 FAZ 面积与较低的 FMT 相关（P<0.0001）。男性仅与 SCP 灌注密度增加相关（P=0.042）。CC 灌注密度增加与年龄较小相关（P=0.022）。
我们报告了健康受试者的儿科 OCTA 参数数据。几个变量影响黄斑微血管网络的密度，在儿科眼部疾病的 OCTA 研究中应考虑这些因素。
