Marosvölgyi-Haskó Diána, Lengyel Blanka, Tukacs József M, Kollár László, Mika László T
Department of Inorganic Chemistry, University of Pécs, János Szentágothai Research Center, MTA-PTE Research Group for Selective Chemical Syntheses, Ifjúság u. 6., 7624, Pécs, Hungary.
János Szentágothai Research Center, MTA-PTE Research Group for Selective Chemical Syntheses, Ifjúság útja 20., 7624, Pécs, Hungary.
Chempluschem. 2016 Nov;81(11):1224-1229. doi: 10.1002/cplu.201600389. Epub 2016 Sep 28.
γ-Valerolactone (GVL) was proposed as a renewable, nontoxic reaction medium with negligible vapor pressure for homogeneous Pd-catalyzed aminocarbonylation reactions. Iodobenzene as a model substrate and its 4-substituted derivatives were converted to the corresponding 2-ketocarboxamides with high conversions and chemoselectivities in γ-valerolactone. The effect of carbon monoxide pressure and reaction temperature on the conversion and selectivities were studied in the range 1-50 bar and 25-100 °C, respectively. The highest conversion and selectivity was achieved at 25 bar and 50 °C for iodobenzene in GVL for 24 h.
γ-戊内酯（GVL）被提议作为一种可再生、无毒且蒸气压可忽略不计的反应介质，用于均相钯催化的氨甲酰化反应。以碘苯作为模型底物及其4-取代衍生物，在γ-戊内酯中可高效转化为相应的2-酮羧酰胺，转化率和化学选择性都很高。分别研究了一氧化碳压力和反应温度在1-50 巴和25-100 °C范围内对转化率和选择性的影响。在GVL中，碘苯于25 巴和50 °C反应24小时时，可实现最高的转化率和选择性。
