Lo H B, Herold M, Reul H, Mückter H, Taguchi K, Surmann M, Hildinger K H, Lambertz H, de Haan H, Handt S
Department of Thoracic and Cardiovascular Surgery, RWTH Aachen, FRG.
ASAIO Trans. 1988 Jul-Sep;34(3):839-44.
The main disadvantages of today's heart valve prostheses are the need for lifelong anticoagulation for mechanical valves and problems with biodegradation for tissue valves. Therefore, a new valve type devoid of these problems would be a major step forward. In order to evaluate a new valve design made by dipmolding with different PU materials, an animal test series was carried out in which two valves from each material were implanted into the mitral position of growing Jersey calves. The surgical procedure and postoperative catheterization data are presented. The survival times ranged between 127 and 291 days. Organs and explanted valves were examined post mortem according to general pathology standards. Specifically, the valves were histologically examined for calcium deposits and investigated by light microscopy, REM and EDAX. All explanted valves showed calcification and immobilization, but the results suggest that at least two PU materials attain survival times which are far beyond the lifetime of bioprostheses under the same implant conditions, justifying further in vivo studies in adult animals.
当今心脏瓣膜假体的主要缺点是机械瓣膜需要终身抗凝，而组织瓣膜存在生物降解问题。因此，一种没有这些问题的新型瓣膜将是向前迈出的重要一步。为了评估用不同聚氨酯材料通过浸塑制成的新型瓣膜设计，开展了一系列动物试验，将每种材料的两个瓣膜植入生长中的泽西小牛的二尖瓣位置。文中介绍了手术过程和术后导管插入数据。存活时间在127天至291天之间。根据一般病理学标准对器官和取出的瓣膜进行了尸检。具体而言，对瓣膜进行了组织学检查以查看是否有钙沉积，并通过光学显微镜、扫描电子显微镜和能谱分析进行了研究。所有取出的瓣膜均显示出钙化和固定，但结果表明，至少有两种聚氨酯材料在相同植入条件下的存活时间远远超过生物假体的使用寿命，这为在成年动物中进一步开展体内研究提供了依据。
