Nix Kimberley M, Harrison Karen J, Shivakumar Sudeep P, Shawwa Allam A, Conrad David M
Department of Medicine, Dalhousie University Halifax, Nova Scotia, Canada.
Department of Pathology and Laboratory Medicine, Dalhousie University Halifax, Nova Scotia, Canada.
Int J Clin Exp Pathol. 2017 Nov 1;10(11):11206-11210. eCollection 2017.
Acute leukemia in adults is usually associated with a myeloid phenotype, and less commonly presents as an acute lymphocytic leukemia. Rarely, the leukemic blast cells express more than one lineage phenotype and satisfy the diagnostic criteria for an acute leukemia of ambiguous lineage (ALAL), further subclassified as mixed phenotype acute leukemia (MPAL). Near-tetraploidy is an unusual presentation of acute leukemia where the blasts contain 80-104 chromosomes. More commonly associated with acute lymphocytic leukemia, near-tetraploidy has been described in only a limited number of cases of acute myeloid leukemias, and near-tetraploid ALAL is rare. We describe the first report of near-tetraploid MPAL, B/myeloid, not otherwise specified.
成人急性白血病通常与髓系表型相关，较少表现为急性淋巴细胞白血病。极少数情况下，白血病原始细胞表达不止一种谱系表型，并符合急性模糊谱系白血病（ALAL）的诊断标准，后者进一步细分为混合表型急性白血病（MPAL）。近四倍体是急性白血病的一种不寻常表现，其中原始细胞含有80 - 104条染色体。近四倍体更常与急性淋巴细胞白血病相关联，仅在少数急性髓系白血病病例中有所描述，而近四倍体ALAL则很罕见。我们报告了首例近四倍体MPAL，B/髓系，未另行说明的病例。
