不同程度低灌注诱导的大鼠脑微血管内皮细胞凋亡特征
Apoptotic cell characteristics of rat brain microvascular endothelia induced by different degrees of hypoperfusion.
作者信息
Tian Shan, Wu Junfa, Li Ce, Zhang Bei, Jiang Congyu, Liu Gang, Chen Ying, Qin Wenting, Li Fang, Bai Yulong, Wu Yi, Zhu Yulian
机构信息
Department of Rehabilitation, Huashan Hospital, Fudan University Shanghai, China.
出版信息
Int J Clin Exp Pathol. 2017 Nov 1;10(11):11360-11368. eCollection 2017.
Abstract
Hypoperfusion is one of the common causes of ischemic stroke. In this study, decreased blood perfusion and neurological damage were confirmed in ischemic rats. Further, the effect of different perfusion was researched in vivo. We found that hypoperfusion promoted the apoptosis of rats brain microvascular endothelial cells, and the more serious of hypoperfusion, the more obvious of apoptosis. At the same time, this process was related to Tie-2 receptor on cell membranes and Caspase-3 apoptotic pathways. Hemodynamics was one factors affecting the cerebral infarction.
摘要
低灌注是缺血性中风的常见病因之一。在本研究中，缺血大鼠的脑血流灌注降低及神经损伤得到证实。此外，还在体内研究了不同灌注的影响。我们发现低灌注促进大鼠脑微血管内皮细胞凋亡，且低灌注越严重，凋亡越明显。同时，这一过程与细胞膜上的Tie-2受体及Caspase-3凋亡途径有关。血流动力学是影响脑梗死的因素之一。
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