Li Lifu, Yang Wenjuan, Yue Hui, He Fengjian, Xu Shenghao, Wei Qingzhu, Chen Peisheng, Peng Qianqian, Deng Sanhua, Long Peiqi
Department of Gastroenterology, The Third Affiliated Hospital of Southern Medical University No. 183 Zhongshan Road West, Guangzhou, Guangdong Province, China.
Department of The Fifth Hepatology, The Ninth Hospital of Nanchang Jiangxi Province, China.
Int J Clin Exp Pathol. 2017 Aug 1;10(8):8633-8639. eCollection 2017.
To investigate the expression of NIBP and its clinical significance in early colorectal cancer.
With immunohistochemistry, the expression of NIBP was detected in 23 patients of early colorectal cancer tissues, 102 patients of invasive colorectal cancer tissues, 32 patients of adenoma and 20 patients of normal tissues. The relationship between NIBP expression and clinicopathological characteristic of colorectal cancer were also analyzed.
We found that the positive rates of NIBP was higher in early colorectal cancer tissues (82.6%, 19/23) than those in adenomas and normal tissues (x=29.07, P<0.05), but not significant than those in invasive colorectal cancer (x=1.79, P>0.05). Positivity for T1N0M0, T2N0M0, II, III and IV was 82.6% (19/23), 80.0% (4/5), 78.0% (32/41), 63.6% (21/33), 56.5% (13/23), respectively. With the increase in TNM stage, the positive rate of NIBP decreased, the positive rate of T1N0M0 is highest than other TNM stages, but no statistically significant (P>0.05).
These results suggested that NIBP is highly expressed in human early colorectal cancer tissues. NIBP might involve in the tumorigenesis and probably serve as a new marker for human early colorectal cancer.
探讨NIBP在早期结直肠癌中的表达及其临床意义。
采用免疫组织化学方法检测23例早期结直肠癌组织、102例浸润性结直肠癌组织、32例腺瘤及20例正常组织中NIBP的表达。分析NIBP表达与结直肠癌临床病理特征的关系。
我们发现早期结直肠癌组织中NIBP的阳性率（82.6%，19/23）高于腺瘤和正常组织（χ=29.07，P<0.05），但与浸润性结直肠癌相比差异无统计学意义（χ=1.79，P>0.05）。T1N0M0、T2N0M0、Ⅱ、Ⅲ和Ⅳ期的阳性率分别为82.6%（19/23）、80.0%（4/5）、78.0%（32/41）、63.6%（21/33）、56.5%（13/23）。随着TNM分期增加，NIBP阳性率降低，T1N0M0期阳性率最高，与其他TNM分期相比差异无统计学意义（P>0.05）。
这些结果提示NIBP在人早期结直肠癌组织中高表达。NIBP可能参与肿瘤发生，有可能作为人早期结直肠癌的一个新标志物。
