Vedernikov Iu P, Lankin V Z, Tikhaze A K, Vikhert A M
Biull Eksp Biol Med. 1988 Nov;106(11):515-7.
Lipoproteins (very low, low and high density) purified from canine fresh plasma produced relaxation of isolated dog coronary artery and rabbit aortic ring segments precontracted with potassium, 30 mM or phenylephrine, 10(-6) M, respectively. No apparent species-specific effects of lipoproteins were revealed and they produced relaxation of other species vessels as well, which differed quantitatively. No apparent endothelium-dependent relaxation produced by animals' lipoproteins was evident. The interference of lipoproteins with some steps in electromechanical coupling is suggested which seemingly result to decrease in excitability of voltage and receptor operated calcium channels of smooth muscle cell membrane. The role of lipoproteins seems to be in maintenance of low level of smooth muscle cell membrane excitability.
从犬新鲜血浆中纯化的脂蛋白（极低密度、低密度和高密度）可使分别用30 mM钾或10⁻⁶ M去氧肾上腺素预收缩的离体犬冠状动脉和兔主动脉环段舒张。未发现脂蛋白有明显的物种特异性作用，它们也能使其他物种的血管舒张，只是在程度上有所不同。未观察到动物脂蛋白产生明显的内皮依赖性舒张作用。提示脂蛋白对机电偶联的某些步骤有干扰，这似乎导致平滑肌细胞膜电压门控性钙通道和受体操纵性钙通道的兴奋性降低。脂蛋白的作用似乎是维持平滑肌细胞膜的低兴奋性水平。
