Katz J, Levin A B
Anesthesiology. 1977 Feb;46(2):115-21. doi: 10.1097/00000542-197702000-00006.
The technique of "chemical hypophysectomy" was modified for the management of pain due to metastatic cancer. Using stereotaxic control, a needle is introduced via the nose into the sella turcica. Absolute alcohol is then injected into the pituitary. Of 13 patients who had severe uncontrollable pain, 11 obtained marked symptomatic relief. The longest follow-up period to date is seven months, with results persisting. Sequelae are those associated with destruction of the pituitary gland, the most significant being diabetes insipidus. Several cerebrospinal fluid leaks prompted us routinely to instill alpha-ethyl cyanoacrylate to seal the sella floor. Three patients had slight extraocular nerve palsies. There was no death related to the procedure.
“化学性垂体切除”技术经改良后用于治疗转移性癌症所致疼痛。通过立体定向控制，将一根针经鼻腔插入蝶鞍。然后将无水酒精注入垂体。13例患有严重且无法控制疼痛的患者中，11例症状明显缓解。目前最长随访期为7个月，效果持续存在。后遗症与垂体破坏相关，最显著的是尿崩症。几例脑脊液漏促使我们常规注入氰基丙烯酸乙酯以封闭蝶鞍底部。3例患者出现轻微的眼外神经麻痹。该手术无相关死亡病例。
