Bouteille B, Darde M L, Pestre-Alexandre M, Dumas M, Breton J C, Nicolas J A, Catanzano G, Munoz M
Service de Parasitologie-Mycologie, C.H.U. Dupuytren, Limoges.
Bull Soc Pathol Exot Filiales. 1988;81(3 Pt 2):616-22.
An experiment was carried out on treatment of Trypanosoma brucei brucei experimentally infected sheep with central nervous system involvement with a 2-nitroimidazole derivative: Ro 15-0216 (Hoffmann La Roche & Co Ltd, Basel, Switzerland). After a single intramuscularly or intravenously administration (25 or 50 mg/kg) of this compound in healthy sheep, levels of more than 1 microgram/ml corresponding to trypanocidal concentrations are detected in both blood and cerebrospinal fluid. However, because of short half life, two or three injections a day appeared to be necessary. Six infected sheep were treated by daily intravenous injection for six days: three animals with 25 mg/kg/d and three others with 50 mg/kg/d. Animals which relapsed received 50 mg/kg/d divided in three intravenous injections a day for six days. After a year of observation, all the animals were considered clinically and biologically cured.
用一种2-硝基咪唑衍生物Ro 15-0216（瑞士巴塞尔霍夫曼·罗氏有限公司）对实验感染布氏布氏锥虫且累及中枢神经系统的绵羊进行了治疗实验。在健康绵羊单次肌肉注射或静脉注射该化合物（25或50毫克/千克）后，在血液和脑脊液中均检测到超过1微克/毫升的锥虫杀灭浓度。然而，由于半衰期短，似乎每天需要注射两到三次。六只感染绵羊每天静脉注射六天：三只动物注射剂量为25毫克/千克/天，另外三只注射剂量为50毫克/千克/天。复发的动物每天分三次静脉注射50毫克/千克，持续六天。经过一年的观察，所有动物在临床和生物学上均被视为治愈。
