Laroche D, Lemonnier F, Viel J F, Travert G, Fernandez Y
Service de Biophysique et Médecine Nucléaire, C.H.R.U. de Caen, France.
Clin Chem. 1988 Dec;34(12):2448-51.
Free triiodothyronine (FT3) has rarely been studied in neonates, primarily because of obvious problems in obtaining serum samples from neonates for research purposes. We adapted an analog radioimmunoassay for measuring FT3 in dried blood samples and used it to assay 361 samples selected from those collected for the screening for neonatal hypothyroidism. The mean FT3 concentration in healthy neonates on the fourth postpartum day is 2.55 pmol per liter of whole blood (SD 0.78 pmol/L, n = 145), the same as in healthy adults. Low-birth-weight infants have a decreased concentration of FT3, and this decrease is much greater in premature neonates than in infants at low weight for gestational age. In six hypothyroid newborns, the FT3 concentration was normal or increased, clearly indicating that FT3 assay is not a diagnostic tool for hypothyroidism. FT3 was barely detectable in one case of congenital galactosemia.
游离三碘甲状腺原氨酸（FT3）在新生儿中的研究很少，主要是因为从新生儿获取血清样本用于研究目的存在明显问题。我们采用一种放射免疫分析类似物来检测干血样本中的FT3，并将其用于检测从新生儿甲状腺功能减退筛查所采集的样本中选取的361份样本。产后第四天健康新生儿的平均FT3浓度为每升全血2.55皮摩尔（标准差0.78皮摩尔/升，n = 145），与健康成年人相同。低体重儿的FT3浓度降低，且这种降低在早产儿中比足月低体重儿更为明显。在6例甲状腺功能减退的新生儿中，FT3浓度正常或升高，这清楚地表明FT3检测并非甲状腺功能减退的诊断工具。在1例先天性半乳糖血症病例中几乎检测不到FT3。
