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一种用于检测活细胞粗面内质网内pH值的萘二亚胺基荧光传感器。

A Naphthalenediimide-Based Fluorescent Sensor for Detecting the pH within the Rough Endoplasmic Reticulum of Living Cells.

作者信息

Ghule Namdev V, Bhosale Rajesh S, Kharat Kiran, Puyad Avinash L, Bhosale Sheshanath V, Bhosale Sidhanath V

机构信息

Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad, Telangana 500007 (India).

RMIT-IICT Research Centre, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad, Telangana 500007 (India).

出版信息

Chempluschem. 2015 Mar;80(3):485-489. doi: 10.1002/cplu.201402307. Epub 2014 Nov 20.

DOI:10.1002/cplu.201402307
PMID:31973408
Abstract

An amino-core-substituted naphthalenediimide (NDI) derivative has been synthesized in good yield in two steps. The NDI bearing a diamine moiety undergoes a reversible protonation-deprotonation process, which results in intensity changes in the absorption and emission spectra. This derivative exhibits good photostability, good selectivity, high sensitivity, and is employed to exhibit the pH within the rough endoplasmic reticulum of living cells.

摘要

一种氨基核心取代的萘二亚胺(NDI)衍生物已通过两步反应以良好的产率合成。带有二胺部分的NDI经历可逆的质子化-去质子化过程,这导致吸收光谱和发射光谱的强度发生变化。该衍生物表现出良好的光稳定性、良好的选择性、高灵敏度,并用于显示活细胞粗面内质网内的pH值。

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