卤代十二硼酸盐簇作为触发脂质体内容物释放的试剂。
Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents.
作者信息
Awad Doaa, Bartok Melinda, Mostaghimi Farzin, Schrader Imke, Sudumbrekar Neeti, Schaffran Tanja, Jenne Carsten, Eriksson Jonny, Winterhalter Mathias, Fritz Jürgen, Edwards Katarina, Gabel Detlef
机构信息
Department of Biochemistry, Faculty of Science, Alexandria University, Moharam Bek, 21511 Alexandria (Egypt).
Department of Chemistry, University of Bremen, PO Box 330440, 28334 Bremen (Germany).
出版信息
Chempluschem. 2015 Apr;80(4):656-664. doi: 10.1002/cplu.201402286. Epub 2015 Jan 12.
Halogenated dodecaborates, and especially dodecaiodododecaborate(2-), are found to trigger effectively the release of the contents of phospholipid liposomes, including liposomes containing distearoylphosphatidylcholine and cholesterol, which are used clinically in cancer therapy. The basis of the release is studied through differential scanning calorimetry, cryo-transmission electron microscopy, and atomic force microscopy. Upon administration at high concentrations, drastic morphological changes are induced by the dodecaborates. Their possible use in triggered release is suggested.
卤代十二硼酸盐，尤其是十二碘十二硼酸盐（2-），被发现能有效触发磷脂脂质体内容物的释放，包括含有二硬脂酰磷脂酰胆碱和胆固醇的脂质体，这些脂质体在癌症治疗中具有临床应用。通过差示扫描量热法、低温透射电子显微镜和原子力显微镜研究了释放的基础。在高浓度给药时，十二硼酸盐会引起剧烈的形态变化。有人提出它们在触发释放方面的可能用途。
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