Assaf Khaleel I, Nau Werner M
Department of Life Sciences and Chemistry, Jacobs University Bremen, Campus Ring 1, 28759, Bremen, Germany.
Angew Chem Int Ed Engl. 2018 Oct 22;57(43):13968-13981. doi: 10.1002/anie.201804597. Epub 2018 Sep 27.
Following up on scattered reports on interactions of conventional chaotropic ions (for example, I , SCN , ClO ) with macrocyclic host molecules, biomolecules, and hydrophobic neutral surfaces in aqueous solution, the chaotropic effect has recently emerged as a generic driving force for supramolecular assembly, orthogonal to the hydrophobic effect. The chaotropic effect becomes most effective for very large ions that extend beyond the classical Hofmeister scale and that can be referred to as superchaotropic ions (for example, borate clusters and polyoxometalates). In this Minireview, we present a continuous scale of water-solute interactions that includes the solvation of kosmotropic, chaotropic, and hydrophobic solutes, as well as the creation of void space (cavitation). Recent examples for the association of chaotropic anions to hydrophobic synthetic and biological binding sites, lipid bilayers, and surfaces are discussed.
继关于传统离液序列高子（例如，I⁻、SCN⁻、ClO₄⁻）与大环主体分子、生物分子以及水溶液中疏水中性表面相互作用的零散报道之后，离液序列效应最近已成为超分子组装的一种通用驱动力，与疏水效应相互独立。对于超出经典霍夫迈斯特序列范围的非常大的离子（可称为超离液序列离子，例如硼酸盐簇和多金属氧酸盐），离液序列效应最为有效。在这篇小型综述中，我们展示了一个连续的水 - 溶质相互作用范围，其中包括对促溶剂化、离液序列化和疏水性溶质的溶剂化作用，以及空隙空间（空化）的产生。讨论了离液序列阴离子与疏水合成和生物结合位点、脂质双层以及表面缔合的最新实例。
