种族和民族差异对严重主动脉瓣狭窄治疗和结局的影响:综述。
Racial and Ethnic Differences in Treatment and Outcomes of Severe Aortic Stenosis: A Review.
机构信息
Albany State University, Albany, Georgia.
Duke Clinical Research Institute, Durham, North Carolina.
出版信息
JACC Cardiovasc Interv. 2020 Jan 27;13(2):149-156. doi: 10.1016/j.jcin.2019.08.056.
Aortic stenosis (AS) is among the most common valvular heart diseases encountered in the United States. In this review the authors examine differences between racial and ethnic groups in the epidemiology and management of severe AS, explore potential explanations for these findings, and discuss the implications for improving the delivery of care to racially and ethnically diverse populations. Underrepresented racial and ethnic groups experience a paradoxically lower prevalence or incidence of AS relative to white subjects, despite having a higher prevalence of traditional risk factors. Historically, UREGs with severe AS have had lower rates of both surgical and transcatheter aortic valve replacement and experienced more post-surgical complications, including, bleeding, worsening heart failure, and rehospitalization. Last, UREGs with severe AS have an increased risk for morbidity and mortality relative to white patients. To date much of the research on AS has examined black-white differences, so there is a need to understand how other racial and ethnic groups with severe AS are diagnosed and treated, with examination of their resulting outcomes. Overall, racial and ethnic disparities in health care access and care delivery are a public health concern given the changing demographics of the U.S. population. These differences in AS management and outcomes highlight the need for additional research into contributing factors and appropriate interventions to address the lower rates of aortic valve replacement and higher morbidity and mortality among UREGs.
主动脉瓣狭窄(AS)是美国最常见的瓣膜性心脏病之一。在这篇综述中,作者研究了不同种族和族裔群体在严重 AS 的流行病学和管理方面的差异,探讨了这些发现的潜在解释,并讨论了改善向不同种族和族裔人群提供护理的意义。代表性不足的种族和族裔群体的 AS 患病率或发病率相对白人受试者反而较低,尽管他们具有更高的传统危险因素患病率。从历史上看,严重 AS 的 UREG 患者的手术和经导管主动脉瓣置换术的比例均较低,且术后并发症更多,包括出血、心力衰竭恶化和再住院。最后,严重 AS 的 UREG 患者的发病率和死亡率相对白人患者更高。迄今为止,AS 的大部分研究都考察了黑人和白人之间的差异,因此需要了解其他严重 AS 的种族和族裔群体的诊断和治疗方法,并研究其结果。总的来说,医疗保健机会和护理提供方面的种族和族裔差异是一个公共卫生关注点,因为美国人口的构成正在发生变化。AS 管理和结果方面的这些差异突出表明,需要进一步研究促成因素和适当的干预措施,以解决 UREG 中主动脉瓣置换率较低以及发病率和死亡率较高的问题。