Moritz D L, Silverman R A
Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106.
Cutis. 1988 Nov;42(5):437-9.
A patient with steatocystoma multiplex was treated with 0.75 mg per kg per day of oral isotretinoin. After one month of minimal improvement the patient discontinued therapy. Over the next two months he noted some shrinkage of his pre-existing lesions, which persisted for a follow-up period of six months. Isotretinoin may show a beneficial response in some cases of steatocystoma multiplex even after use of the drug is discontinued. Isotretinoin is known to have effects beyond its treatment period that are related to its long serum half-life. A small number of patients with steatocystoma multiplex have been treated with isotretinoin, with varied responses. This is the first case of a patient who discontinued therapy before a response occurred and then showed a response later.
一名患有多发性皮脂腺囊肿的患者接受了每天每公斤体重0.75毫克的口服异维A酸治疗。经过一个月仅有轻微改善后，患者停止了治疗。在接下来的两个月里，他注意到先前存在的病变有一些缩小，这种情况在六个月的随访期内持续存在。即使在停用异维A酸后，异维A酸在一些多发性皮脂腺囊肿病例中可能仍会显示出有益的反应。已知异维A酸在其治疗期之后仍有作用，这与其较长的血清半衰期有关。少数患有多发性皮脂腺囊肿的患者接受了异维A酸治疗，反应各不相同。这是第一例在出现反应前停止治疗、之后又出现反应的患者。
