人类慢性肉芽肿病X连锁基因在小鼠X染色体上的定位：对X染色体进化的意义
Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution.
作者信息
Brockdorff N, Fisher E M, Orkin S H, Lyon M F, Brown S D
机构信息
Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, UK.
出版信息
Cytogenet Cell Genet. 1988;48(2):124-5. doi: 10.1159/000132605.
PMID:3197451
Abstract
The gene encoded at the human X-linked chronic granulomatous disease locus (cytochrome b245 beta subunit) has been mapped to the mouse X chromosome using an interspecific Mus domesticus x M. spretus cross. The localization of this gene provides detailed information on one of the proposed ancestral breakpoints that account for the divergent evolution of the mouse and human X chromosomes.
摘要
利用家鼠（Mus domesticus）与西班牙小鼠（M. spretus）的种间杂交，已将人类X连锁慢性肉芽肿病位点（细胞色素b245β亚基）编码的基因定位到小鼠X染色体上。该基因的定位为解释小鼠和人类X染色体趋异进化的一个假定祖先断点提供了详细信息。
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