Arisaka O, Shimura N, Nakayama Y, Arisaka M, Yabuta K
Abteilung für Pädiatrie, Juntendo Medizinische Universitätsklinik, Tokio, Japan.
Dtsch Med Wochenschr. 1988 Dec 9;113(49):1913-5. doi: 10.1055/s-2008-1067911.
The salivary concentration of 17-hydroxyprogesterone (17-OHP) was determined in 11 patients (aged 6 months to 13 years) with congenital adrenogenital syndrome (AGS) due to C21-hydroxylase deficiency and six healthy controls, in order to assess its value in monitoring treatment of AGS. Salivary 17-OHP was measured by a specific radioimmunoassay after extraction with dichloromethane. Only 100 microliters of saliva was needed for the assay. There was a good correlation (r = 0.93; P less than 0.01) between 17-OHP concentrations in paired saliva and serum samples from the patients and the control subjects. There was a wide scatter in salivary 17-OHP levels in the range between 164 ng/l (1.7 ng/ml in serum) of satisfactorily or overtreated patients and 15,500 ng/l (247 ng/l in serum) of undertreated patients. Levels in normal children were between 200 and 300 ng/l. It is concluded that treatment of congenital AGS (21-hydroxylase deficiency) can be carefully monitored in children with the noninvasive, frequently repeatable measurement of salivary 17-OHP.
为评估唾液中17-羟孕酮（17-OHP）在先天性肾上腺皮质增生症（AGS）治疗监测中的价值，对11例因21-羟化酶缺乏所致先天性肾上腺皮质增生症的患者（年龄6个月至13岁）及6名健康对照者的唾液17-OHP浓度进行了测定。用二氯甲烷提取后，通过特异性放射免疫分析法测定唾液17-OHP。该检测仅需100微升唾液。患者及对照者配对的唾液和血清样本中17-OHP浓度之间存在良好的相关性（r = 0.93；P < 0.01）。在治疗满意或过度治疗的患者中，唾液17-OHP水平为164 ng/l（血清中为1.7 ng/ml），而治疗不足的患者中该水平为15,500 ng/l（血清中为247 ng/l），两者之间唾液17-OHP水平差异很大。正常儿童的水平在200至300 ng/l之间。结论是，通过对唾液17-OHP进行非侵入性、可频繁重复的测量，可以对先天性AGS（21-羟化酶缺乏）患儿的治疗进行仔细监测。
