Departments of Internal Medicine and Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA.
Curr Opin Crit Care. 2020 Apr;26(2):186-191. doi: 10.1097/MCC.0000000000000700.
ICU admissions due to complications of advanced liver disease continue to rise. Among indications for admission to the ICU in patients with cirrhosis, gastrointestinal issues such as bleeding are common. In patients in whom gastrointestinal issues are not the principal indication for ICU, gastrointestinal issues such as nutrition and ileus remain important concerns for generalized intensive care support. This review highlights current trends in management of gastrointestinal issues in patients with cirrhosis admitted to the ICU.
General management of upper gastrointestinal bleeding remains largely unchanged. Improvements in interventional techniques have increased the options for difficult to control bleeding, these include the development of expandable esophageal stents and expanded experience with advanced interventional radiology techniques for the management of bleeding gastric varices. Frailty as an important prognostic marker in advanced liver disease and liver transplantation is the subject of several new studies and serves to highlight the importance of nutrition in the management of the critically ill cirrhotic patient.
Gastrointestinal complications are frequent in the critically ill cirrhotic patient. Recognition and intervention in a timely manner may minimize morbidity and mortality and result in improved outcomes for this vulnerable population.
因晚期肝脏疾病并发症而入住 ICU 的人数持续上升。在肝硬化患者入住 ICU 的适应证中,胃肠道出血等问题较为常见。对于胃肠道问题并非 ICU 主要适应证的患者,胃肠道问题(如营养和肠梗阻)仍然是普遍加强监护支持的重要关注点。本文重点介绍目前 ICU 收治的肝硬化患者胃肠道问题的管理趋势。
上消化道出血的一般治疗方法基本保持不变。介入技术的改进增加了治疗难以控制出血的选择,包括可扩张食管支架的发展以及在治疗胃静脉曲张出血方面扩大应用先进介入放射学技术的经验。在晚期肝脏疾病和肝移植中,衰弱是一个重要的预后标志物,这是几项新研究的主题,突出了营养在治疗危重症肝硬化患者中的重要性。
胃肠道并发症在重症肝硬化患者中很常见。及时识别和干预可能会降低发病率和死亡率,并改善这一脆弱人群的预后。