Lee Jungwhoi, Lee Jungsul, Sim Woogwang, Kim Jae-Hoon
Department of Applied Life Science, SARI, Jeju National University, Jeju-do 63243, Korea.
Department of Bio and Brain Engineering, KAIST, Daejeon 34141, Korea.
Cancers (Basel). 2020 Jan 23;12(2):277. doi: 10.3390/cancers12020277.
Even though the tumour suppressive role of PTEN is well-known, its prognostic implications are ambiguous. The objective of this study was to further explore the function of PTEN expression in human pancreatic cancer. The expression of PTEN has been dominant in various human cancers including pancreatic cancer when compared with their matched normal tissues. The pancreatic cancer cells have been divided into PTEN blockade-susceptible and PTEN blockade-impassible groups dependent on targeting PTEN by altering intracellular signaling. The expression of PTEN has led to varying clinical outcomes of pancreatic cancer based on GEO Series (GSE) data analysis and Liptak's z analysis. Differential dependency to PTEN blockade has been ascertained based on the expression of polo-like kinase1 PLK1 in pancreatic cancer cells. The prognostic value of PTEN also depends on PLK1 expression in pancreatic cancer. Collectively, the present study provides a rationale for targeting PTEN as a promising therapeutic strategy dependent on PLK1 expressions using a companion biomarker discovery platform.
尽管PTEN的肿瘤抑制作用广为人知，但其预后意义却不明确。本研究的目的是进一步探讨PTEN表达在人类胰腺癌中的作用。与匹配的正常组织相比，PTEN的表达在包括胰腺癌在内的各种人类癌症中占主导地位。通过改变细胞内信号靶向PTEN，将胰腺癌细胞分为对PTEN阻断敏感和对PTEN阻断不敏感的组。基于GEO数据集（GSE）分析和利普塔克z分析，PTEN的表达导致了胰腺癌不同的临床结果。根据胰腺癌细胞中polo样激酶1（PLK1）的表达确定了对PTEN阻断的差异依赖性。PTEN的预后价值也取决于胰腺癌中PLK1的表达。总的来说，本研究为使用伴随生物标志物发现平台，将PTEN作为一种基于PLK1表达的有前景的治疗策略提供了理论依据。
