牙齿发育、稳态和修复的分子和细胞机制。
Molecular and cellular mechanisms of tooth development, homeostasis and repair.
机构信息
Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA 94143, USA.
Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA 94143, USA
出版信息
Development. 2020 Jan 24;147(2):dev184754. doi: 10.1242/dev.184754.
Abstract
The tooth provides an excellent system for deciphering the molecular mechanisms of organogenesis, and has thus been of longstanding interest to developmental and stem cell biologists studying embryonic morphogenesis and adult tissue renewal. In recent years, analyses of molecular signaling networks, together with new insights into cellular heterogeneity, have greatly improved our knowledge of the dynamic epithelial-mesenchymal interactions that take place during tooth development and homeostasis. Here, we review recent progress in the field of mammalian tooth morphogenesis and also discuss the mechanisms regulating stem cell-based dental tissue homeostasis, regeneration and repair. These exciting findings help to lay a foundation that will ultimately enable the application of fundamental research discoveries toward therapies to improve oral health.
摘要
牙齿为解析器官发生的分子机制提供了一个极好的系统，因此一直以来都受到研究胚胎形态发生和成人组织更新的发育和干细胞生物学家的关注。近年来，对分子信号网络的分析以及对细胞异质性的新认识，极大地提高了我们对牙齿发育和稳态过程中发生的动态上皮-间充质相互作用的认识。在这里，我们回顾了哺乳动物牙齿形态发生领域的最新进展，并讨论了调节基于干细胞的牙齿组织稳态、再生和修复的机制。这些令人兴奋的发现有助于为最终将基础研究发现应用于改善口腔健康的治疗方法奠定基础。
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