School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.
Arch Pharm Res. 2020 Jan;43(1):134-152. doi: 10.1007/s12272-020-01208-3. Epub 2020 Jan 24.
Together with the development of nanoscience, lanthanide (Ln)-doped upconversion nanoparticles (UCNPs), which can emit UV/VIS light upon irradiation by near-infrared laser sources, is emerging as one of the most favorable materials in the field of nanomedicines. Light-responsive drug delivery is known as an efficient strategy to achieve temporal and spatial controlled drug release. Compared to conventional light-sensitive drug delivery systems, UCNPs are endowed with many advantages, such as deeper tissue penetration and low toxicity. With their unique properties, UCNPs not only serve as potential optical probes for bioimaging but also perform a critical role in therapeutic applications through photon-triggered mechanisms. In particular, UCNPs in combination with different materials and delivery strategies could overcome therapy resistance and enhance therapeutic effectiveness. This article focuses on the current achievements in the last decade of modification methods, diagnostics, and designs of UCNP-based nanoplatforms for successful phototherapy, chemotherapy, and bioimaging.
随着纳米科学的发展，镧系元素（Ln）掺杂的上转换纳米粒子（UCNPs）在近红外激光源照射下能发射紫外/可见光，正成为纳米医学领域最有前途的材料之一。光响应药物输送被认为是实现时间和空间控制药物释放的有效策略。与传统的光敏感药物输送系统相比，UCNPs 具有许多优点，如更深的组织穿透性和低毒性。UCNPs 凭借其独特的性质，不仅可用作生物成像的潜在光学探针，而且还通过光子触发机制在治疗应用中发挥关键作用。特别是，UCNPs 与不同的材料和输送策略相结合，可以克服治疗耐药性并提高治疗效果。本文重点介绍了过去十年中 UCNP 基纳米平台在光疗、化疗和生物成像方面的修饰方法、诊断和设计的最新成果。
