葡萄糖-6-磷酸脱氢酶变异体及其在中国广东的频率。
Glucose-6-phosphate dehydrogenase variants and their frequency in Guangdong, China.
作者信息
Du C S, Xu Y K, Hua X Y, Wu Q L, Liu L B
机构信息
Department of Medical Genetics, Sun Yat Sen University of Medical Sciences, Guangzhou, The People's Republic of China.
出版信息
Hum Genet. 1988 Dec;80(4):385-8. doi: 10.1007/BF00273657.
Erythrocyte glucose-6-phosphate dehydrogenase (G6PD) was characterized in blood samples obtained from 97 randomly selected males with enzyme deficiency from various regions of Guangdong Province, China. Nine new variants (Gd Kaiping, Gd Boluo, Gd Huiyang, Gd Gaomin, Gd Qing-Baijiang, Gd Gaozhou, Gd Huazhou, Gd Nanhai, and Gd Guangzhou) were identified. Of the 31 variants found in this province, Gd Kaiping, Gd Taiwan-Hakka, Gd Haad Yai, Gd Haad Yai-like and Gd Huiyang occurred most frequently. The frequency of each variant was calculated. The results demonstrated that the genetic heterogeneity of G6PD deficiency was high in this area.
对从中国广东省不同地区随机选取的97名酶缺乏男性的血样进行了红细胞葡萄糖-6-磷酸脱氢酶（G6PD）特性分析。鉴定出9种新变异型（Gd开平、Gd博罗、Gd惠阳、Gd高明、Gd青白江、Gd高州、Gd化州、Gd南海和Gd广州）。在该省发现的31种变异型中，Gd开平、Gd台湾客家、Gd合艾、Gd类合艾和Gd惠阳出现频率最高。计算了每种变异型的频率。结果表明，该地区G6PD缺乏的遗传异质性很高。
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