School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China.
School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China.
J Pharm Biomed Anal. 2020 Mar 20;181:113103. doi: 10.1016/j.jpba.2020.113103. Epub 2020 Jan 9.
Sodium ascorbyl phosphate is a hydrophilic derivative of ascorbic acid with better stability compared to the parent compound. However, sodium ascorbyl phosphate is not as stable in solution as it is in the solid state, and it has been found to degrade, with accompanying discoloration, under the influence of different conditions. Here, the degradation mechanism of sodium ascorbyl phosphate in the water-glycerol system was revealed and the thermal degradation kinetics was shown to follow second-order kinetics. A thermal degradation prediction model was established and successfully fitted to the experimental data. In addition, the stability of sodium ascorbyl phosphate in the water-glycerol system during storage was investigated under different conditions, including changes in concentration, temperature, pH, light and oxygen, and metal ions. Sodium ascorbyl phosphate content was quantitatively measured via HPLC, and the color and pH values of the sample were qualitatively measured using a spectrophotometer and a pH meter, respectively. It was found that temperature and pH are the most important factors affecting the stability of sodium ascorbyl phosphate.
磷酸抗坏血酸钠是抗坏血酸的亲水性衍生物，与母体化合物相比稳定性更好。然而，磷酸抗坏血酸钠在溶液中的稳定性不如在固态时好，并且已经发现它会在不同条件的影响下降解，伴随着变色。在这里，揭示了磷酸抗坏血酸钠在水-甘油体系中的降解机制，并表明其热降解动力学遵循二级动力学。建立了热降解预测模型，并成功拟合了实验数据。此外，还在不同条件下（包括浓度、温度、pH 值、光照和氧气以及金属离子的变化）研究了磷酸抗坏血酸钠在水-甘油体系中的储存稳定性。通过 HPLC 定量测量了磷酸抗坏血酸钠的含量，并使用分光光度计和 pH 计分别定性测量了样品的颜色和 pH 值。结果发现，温度和 pH 值是影响磷酸抗坏血酸钠稳定性的最重要因素。
