Phillips D H, Hewer A, Grover P L, Jass J R
Chester Beatty Laboratories, Institute of Cancer Research, London, UK.
IARC Sci Publ. 1988(89):368-71.
The incidence of colorectal cancer in the western hemisphere is though to be the result, in part, of environmental agents, and many studies strongly implicate diet as a determining factor. It is conceivable that the ingestion of genotoxic chemicals present in food or the endogenous formation of such substances in the gut may initiate colorectal cancer in humans. In the present study, 32P-postlabelling has been used to examine DNA from normal-appearing colonic mucosa obtained from (i) patients undergoing surgery for colorectal cancer and (ii) adult and fetal controls for the presence of aromatic DNA adducts.
西半球结直肠癌的发病率被认为部分是环境因素所致，许多研究有力地表明饮食是一个决定性因素。可以想象，摄入食物中存在的基因毒性化学物质或肠道中此类物质的内源性形成可能引发人类结直肠癌。在本研究中，32P后标记法已被用于检测从以下来源获得的外观正常的结肠黏膜DNA：（i）接受结直肠癌手术的患者，以及（ii）成年和胎儿对照，以检测芳香族DNA加合物的存在。
