人造矿物纤维诱导形成DNA加合物8-羟基-2'-脱氧鸟苷。
Formation of DNA adduct 8-hydroxy-2'-deoxyguanosine induced by man-made mineral fibres.
作者信息
Leanderson P, Söderkvist P, Tagesson C, Axelson O
机构信息
Department of Occupational Medicine, Faculty of Health Sciences, Linköping, Sweden.
出版信息
IARC Sci Publ. 1988(89):422-4.
PMID:3198230
Abstract
Two man-made mineral fibres, rockwool and glasswool, were found to mediate hydroxylation of deoxyguanosine and calf thymus DNA to form the DNA adduct 8-hydroxy-2'-deoxyguanosine. The modification of the nucleoside is probably mediated by hydroxyl radicals and may play a role in fibre-induced carcinogenesis.
摘要
研究发现，两种人造矿物纤维，即岩棉和玻璃棉，可介导脱氧鸟苷和小牛胸腺DNA的羟基化反应，形成DNA加合物8-羟基-2'-脱氧鸟苷。核苷的这种修饰可能是由羟基自由基介导的，并且可能在纤维诱导的致癌过程中发挥作用。
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