Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Ophthalmol Retina. 2020 Mar;4(3):231-237. doi: 10.1016/j.oret.2019.11.015. Epub 2019 Nov 21.
To evaluate differences in the progression pattern among subtypes of retinopathy of prematurity (ROP).
Retrospective cohort study.
Premature infants screened for ROP.
Medical records of 578 premature infants who were screened at the neonatal intensive care unit from September 2009 through March 2016 were reviewed. We matched for the number of patients, gestational age at birth, and postmenstrual age at the first examination between infants with spontaneously regressed ROP and those with treated ROP. A total of 133 premature infants who were born before 27 weeks' gestation were included.
The mean age at onset of any ROP and the duration from the initial examination to onset were compared between infants with regressed ROP and those with treated ROP. The mean age at treatment and the duration from onset to treatment were compared between infants with type 1 ROP and those with aggressive posterior ROP (AP-ROP). Data were analyzed for 1 randomly selected eye for each infant.
Of 133 premature infants with any ROP, 67 regressed spontaneously, 43 demonstrated type 1 ROP, and 23 demonstrated AP-ROP. Individual trajectories of ROP progression over time showed that AP-ROP progressed through the stages in a steep linear manner in most cases. In contrast, the type 1 ROP and regressed ROP developed in a slower, stepwise manner.
In infants with ROP, the disease trajectories across ROP stages are different based on the ROP subtype, despite postmenstrual age at onset being comparable across subtypes. Our findings could be useful for managing follow-up screening.
评估早产儿视网膜病变（ROP）各亚型的进展模式差异。
回顾性队列研究。
接受 ROP 筛查的早产儿。
对 2009 年 9 月至 2016 年 3 月在新生儿重症监护病房接受 ROP 筛查的 578 例早产儿的病历进行了回顾性分析。我们对自发消退型 ROP 患儿和治疗型 ROP 患儿的患者数量、出生时的胎龄和首次检查时的校正月龄进行了匹配。共纳入 133 例胎龄<27 周的早产儿。
比较消退型 ROP 患儿和治疗型 ROP 患儿发病的平均年龄以及从首次检查到发病的时间间隔。比较 1 型 ROP 患儿和侵袭性后部 ROP（AP-ROP）患儿发病的平均年龄以及从发病到治疗的时间间隔。对每个患儿的每只眼随机选择 1 只眼进行数据分析。
在 133 例患有任何 ROP 的早产儿中，67 例自发消退，43 例为 1 型 ROP，23 例为 AP-ROP。ROP 进展的个体轨迹显示，在大多数情况下，AP-ROP 以陡峭的线性方式快速进展通过各期。相比之下，1 型 ROP 和消退型 ROP 的发展速度较慢，呈阶段性。
尽管各 ROP 亚型的发病校正月龄相当，但 ROP 亚型不同，ROP 各期的疾病轨迹也不同。我们的研究结果可能有助于管理 ROP 患儿的随访筛查。
