神经移位术恢复膈肌功能的实验研究。
Experimental Study of Nerve Transfer to Restore Diaphragm Function.
机构信息
Department of Plastic and Reconstructive Surgery, Shanghai Ninth Peoples' Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.
出版信息
World Neurosurg. 2020 May;137:e75-e82. doi: 10.1016/j.wneu.2020.01.025. Epub 2020 Jan 23.
BACKGROUND
Diaphragmatic paralysis after phrenic nerve injury is an infrequent but serious condition. The destruction of respiratory function after unilateral phrenic nerve injury has been the subject of many investigations.
METHODS
In this study, we used a rat model of complete paralysis of the unilateral diaphragm to observe changes in pulmonary function.
RESULTS
We found in young rats with complete paralysis of the unilateral diaphragm, the vital capacity and total lung capacity show compensation after 4 weeks, and contralateral phrenic nerve transfer can enhance pulmonary function. However, in the aged rats, respiratory function parameters do not show compensation until 16 weeks after injury.
CONCLUSIONS
These findings suggest that contralateral phrenic nerve end-to-side anastomosis is a promising therapeutic strategy. In general, our results suggest that this surgical method may hold great potential to be a secure, feasible, and effective technique to rescue diaphragmatic function.
背景
膈神经损伤后出现膈肌瘫痪是一种不常见但很严重的情况。单侧膈神经损伤后呼吸功能的破坏已经成为许多研究的主题。
方法
在这项研究中，我们使用了一种单侧膈肌完全瘫痪的大鼠模型来观察肺功能的变化。
结果
我们发现，在单侧膈肌完全瘫痪的年轻大鼠中，肺活量和总肺容量在 4 周后出现代偿，而对侧膈神经转移可以增强肺功能。然而，在老年大鼠中，呼吸功能参数直到损伤后 16 周才出现代偿。
结论
这些发现表明，膈神经侧侧吻合术是一种有前途的治疗策略。总的来说，我们的结果表明，这种手术方法可能是一种安全、可行和有效的技术，可以挽救膈肌功能。
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