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切换至克拉屈滨治疗后出现严重芬戈莫德反弹综合征。

Severe fingolimod rebound syndrome after switching to cladribine treatment.

机构信息

The American British Cowdray Medical Center, Mexico City, Mexico.

Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.

出版信息

Mult Scler Relat Disord. 2020 May;40:101938. doi: 10.1016/j.msard.2020.101938. Epub 2020 Jan 16.

DOI:10.1016/j.msard.2020.101938
PMID:31982666
Abstract

We present the clinical and imaging characteristics of a patient whom presented with rebound syndrome after switching from fingolimod to cladribine treatment due to hematologic toxicity. Previous imaging studies had shown a non-aggressive phenotype of the disease, however multiple active tumefactive lesions became evident after beginning treatment with cladribine. The patient responded well to plasmapheresis.

摘要

我们介绍了一位患者的临床和影像学特征,该患者因血液学毒性而从芬戈莫德转换为克拉屈滨治疗后出现反弹综合征。先前的影像学研究显示疾病具有非侵袭性表型,但开始用克拉屈滨治疗后,多个活跃的肿块样病变变得明显。该患者对血浆置换反应良好。

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Severe fingolimod rebound syndrome after switching to cladribine treatment.切换至克拉屈滨治疗后出现严重芬戈莫德反弹综合征。
Mult Scler Relat Disord. 2020 May;40:101938. doi: 10.1016/j.msard.2020.101938. Epub 2020 Jan 16.
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引用本文的文献

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Ther Adv Neurol Disord. 2025 Jan 8;18:17562864241304212. doi: 10.1177/17562864241304212. eCollection 2025.
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Treatment algorithms of relapsing multiple sclerosis: an exploration based on the available disease-modifying therapies in China.复发型多发性硬化的治疗方案:基于中国现有疾病修正治疗的探索
Ther Adv Neurol Disord. 2024 Apr 13;17:17562864241239117. doi: 10.1177/17562864241239117. eCollection 2024.
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Real-World Effectiveness of Cladribine for Patients with Multiple Sclerosis: A Sicilian Multicentric Experience (Rewind Study).
真实世界中克拉屈滨治疗多发性硬化症的疗效:西西里岛多中心经验(Rewind 研究)。
Curr Neuropharmacol. 2024;22(7):1271-1283. doi: 10.2174/1570159X21666230322140711.
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Opportunities and Obstacles Associated With Sequential Immune Reconstitution Therapy for Multiple Sclerosis: A Case Report.多发性硬化症序贯免疫重建疗法的机遇与障碍:病例报告
Front Neurol. 2021 Dec 8;12:664596. doi: 10.3389/fneur.2021.664596. eCollection 2021.