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Chronic Chagas disease with low plasma concentrations of IL-6 does not have a major impact on nebivolol glucuronidation.

作者信息

Vieira Carolina Pinto, Neves Daniel Valente, Nardotto Glauco Henrique Balthazar, Cesarino Evandro José, Rocha Adriana, Zanardi Ailton Marcelo Castilho Teno, Lanchote Vera Lucia

机构信息

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

AMZ-Diagnósticos Médicos, Ribeirão Preto, SP, Brazil.

出版信息

Eur J Clin Pharmacol. 2020 May;76(5):735-737. doi: 10.1007/s00228-020-02837-9. Epub 2020 Jan 25.

DOI:10.1007/s00228-020-02837-9
PMID:31982921
Abstract
摘要

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Chronic Chagas disease with low plasma concentrations of IL-6 does not have a major impact on nebivolol glucuronidation.血浆白细胞介素-6浓度较低的慢性恰加斯病对奈必洛尔葡萄糖醛酸化没有重大影响。
Eur J Clin Pharmacol. 2020 May;76(5):735-737. doi: 10.1007/s00228-020-02837-9. Epub 2020 Jan 25.
2
An indirect stereoselective analysis of nebivolol glucuronides in plasma by LC-MS/MS: Application to clinical pharmacokinetics.液相色谱-串联质谱法对血浆中奈必洛尔葡萄糖醛酸苷的间接立体选择性分析：在临床药代动力学中的应用
J Pharm Biomed Anal. 2017 Sep 10;144:25-30. doi: 10.1016/j.jpba.2017.01.054. Epub 2017 Feb 3.
3
Trypanosoma cruzi infection induces up-regulation of cardiac muscarinic acetylcholine receptors in vivo and in vitro.克氏锥虫感染在体内和体外均可诱导心脏毒蕈碱型乙酰胆碱受体上调。
Braz J Med Biol Res. 2008 Sep;41(9):796-803. doi: 10.1590/s0100-879x2008000900009.
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[C-reactive protein and interleukin-6 serum levels increase as Chagas disease progresses towards cardiac failure].随着恰加斯病进展为心力衰竭，血清C反应蛋白和白细胞介素-6水平升高。
Rev Esp Cardiol. 2006 Jan;59(1):50-6.
5
Evaluation of 24 CYP2D6 Variants on the Metabolism of Nebivolol In Vitro.24种CYP2D6变体对奈必洛尔体外代谢的评估
Drug Metab Dispos. 2016 Nov;44(11):1828-1831. doi: 10.1124/dmd.116.071811. Epub 2016 Aug 18.
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[Lipid metabolism in Chagas' disease. Aspects of the radioactivity curves of the blood after ingestion of triolein labelled with I-131].[恰加斯病中的脂质代谢。摄入用I-131标记的三油酸甘油酯后血液放射性曲线的相关方面]
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Large inter-individual variability in pharmacokinetics of dexmedetomidine and its two major N-glucuronides in adult intensive care unit patients.成人重症监护病房患者中右美托咪定及其两种主要 N-葡萄糖醛酸化物的药代动力学个体间差异较大。
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Trypanosoma cruzi-specific IFN-γ-producing cells in chronic Chagas disease associate with a functional IL-7/IL-7R axis.慢性恰加斯病中克氏锥虫特异性 IFN-γ 产生细胞与功能性 IL-7/IL-7R 轴相关。
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Atrial natriuretic factor in experimental acute Chagas' disease.实验性急性恰加斯病中的心房利钠因子
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Inflammatory and prothrombotic activation with conserved endothelial function in patients with chronic, asymptomatic Chagas disease.慢性无症状恰加斯病患者存在炎症和促血栓形成激活以及内皮功能保持。
Clin Appl Thromb Hemost. 2011 Oct;17(5):502-7. doi: 10.1177/1076029610375814. Epub 2010 Aug 10.

本文引用的文献

1
Intermediate Monocytes and Cytokine Production Associated With Severe Forms of Chagas Disease.中介单核细胞与细胞因子产生与恰加斯病的严重形式相关。
Front Immunol. 2019 Jul 19;10:1671. doi: 10.3389/fimmu.2019.01671. eCollection 2019.
2
An indirect stereoselective analysis of nebivolol glucuronides in plasma by LC-MS/MS: Application to clinical pharmacokinetics.液相色谱-串联质谱法对血浆中奈必洛尔葡萄糖醛酸苷的间接立体选择性分析：在临床药代动力学中的应用
J Pharm Biomed Anal. 2017 Sep 10;144:25-30. doi: 10.1016/j.jpba.2017.01.054. Epub 2017 Feb 3.
3
Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy.
用于治疗恰加斯心肌病患者心力衰竭的药物干预措施。
Cochrane Database Syst Rev. 2016 Jul 8;7(7):CD009077. doi: 10.1002/14651858.CD009077.pub3.
4
Inflammatory and cardiac biomarkers are differentially expressed in clinical stages of Chagas disease.炎症和心脏生物标志物在恰加斯病的临床阶段存在差异表达。
Int J Cardiol. 2015 Nov 15;199:451-9. doi: 10.1016/j.ijcard.2015.07.040. Epub 2015 Jul 12.
5
Impact of visceral leishmaniasis and curative chemotherapy on cytochrome P450 activity in Brazilian patients.内脏利什曼病及根治性化疗对巴西患者细胞色素P450活性的影响
Br J Clin Pharmacol. 2015 Nov;80(5):1160-8. doi: 10.1111/bcp.12677. Epub 2015 Jul 2.
6
A physiologically based pharmacokinetic modeling approach to predict disease-drug interactions: suppression of CYP3A by IL-6.一种基于生理的药代动力学建模方法预测疾病-药物相互作用：IL-6 对 CYP3A 的抑制作用。
Clin Pharmacol Ther. 2013 Aug;94(2):260-8. doi: 10.1038/clpt.2013.79. Epub 2013 Apr 10.
7
Effects of B-Blockers on outcome of patients with Chagas' cardiomyopathy with chronic heart failure.β受体阻滞剂对伴有慢性心力衰竭的恰加斯心肌病患者结局的影响。
Int J Cardiol. 2011 Sep 1;151(2):205-8. doi: 10.1016/j.ijcard.2010.05.033. Epub 2010 Jul 1.
8
Expression of UDP-glucuronosyltransferase 1A6 isoform in Caco-2 cells stimulated with lipopolysaccharide.脂多糖刺激 Caco-2 细胞中 UDP-葡糖醛酸基转移酶 1A6 同工型的表达。
Innate Immun. 2010 Oct;16(5):302-9. doi: 10.1177/1753425909341909. Epub 2009 Aug 26.
9
Regulation of uridine diphosphate glucuronosyltransferase during the acute-phase response.急性期反应过程中尿苷二磷酸葡萄糖醛酸基转移酶的调节
J Gastroenterol Hepatol. 1998 Jan;13(1):88-94. doi: 10.1111/j.1440-1746.1998.tb00551.x.
10
Effect of interleukins on UGT2B15 and UGT2B17 steroid uridine diphosphate-glucuronosyltransferase expression and activity in the LNCaP cell line.白细胞介素对LNCaP细胞系中UGT2B15和UGT2B17类固醇尿苷二磷酸葡萄糖醛酸基转移酶表达及活性的影响。
Endocrinology. 1998 May;139(5):2375-81. doi: 10.1210/endo.139.5.6001.