Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Key Laboratory of Myopia, Ministry of Health, Shanghai, China.
Eur J Ophthalmol. 2021 Mar;31(2):361-366. doi: 10.1177/1120672120902034. Epub 2020 Jan 27.
To evaluate the changes of corneal biomechanics and the intraocular pressure during pregnancy in a Chinese healthy female population.
A total of 222 unrelated Chinese females were recruited: 52 non-pregnant, 15 pregnant in the first trimester, 68 pregnant in the second trimester, and 87 pregnant in the third trimester. The intraocular pressure and corneal biomechanical parameters, including corneal-compensated intraocular pressure, Goldmann-correlated intraocular pressure, corneal hysteresis, and corneal resistance factor, were measured by an Ocular Response Analyzer G3. Central corneal thickness was measured by Lenstar (LS900).
Corneal hysteresis and corneal resistance factor were significantly higher in pregnant women at the second and third trimesters. Corneal-compensated intraocular pressure was lower in women at the third trimester of pregnancy ( = 0.023), but the difference became insignificant after adjustment for corneal hysteresis. Central corneal thickness was marginally higher in pregnant women than non-pregnant women ( = 0.032). There was a negative correlation between corneal-compensated intraocular pressure and corneal hysteresis ( = -0.337, < 0.001) and a positive correlation between central corneal thickness and corneal hysteresis ( = 0.711, < 0.0001). After adjustment for corneal-compensated intraocular pressure, corneal hysteresis remained significantly higher in the second and third trimesters of pregnant women than non-pregnant women ( = 0.031, = 0.005).
This study revealed a significant increase in corneal hysteresis and corneal resistance factor in the second and third trimesters. The increase of corneal hysteresis was independent of corneal-compensated intraocular pressure, indicating pregnant females have unique characteristics in corneal-compensated intraocular pressure and corneal biomechanical properties that may be related to glaucoma and corneal ectatic diseases in pregnancy.
评估中国健康女性人群在怀孕期间角膜生物力学和眼压的变化。
共招募了 222 名无亲缘关系的中国女性：52 名非孕妇，15 名孕早期，68 名孕中期，87 名孕晚期。使用眼反应分析仪 G3 测量眼压和角膜生物力学参数，包括角膜补偿眼压、戈尔曼相关眼压、角膜滞后和角膜阻力因子。使用 Lenstar（LS900）测量中央角膜厚度。
孕中期和孕晚期的角膜滞后和角膜阻力因子明显升高。孕晚期的角膜补偿眼压较低（=0.023），但校正角膜滞后后差异无统计学意义。孕妇的中央角膜厚度略高于非孕妇（=0.032）。角膜补偿眼压与角膜滞后呈负相关（=−0.337，<0.001），中央角膜厚度与角膜滞后呈正相关（=0.711，<0.0001）。校正角膜补偿眼压后，孕中期和孕晚期的角膜滞后仍明显高于非孕妇（=0.031，=0.005）。
本研究显示，在孕中期和孕晚期，角膜滞后和角膜阻力因子显著增加。角膜滞后的增加与角膜补偿眼压无关，表明孕妇的角膜补偿眼压和角膜生物力学特性具有独特特征，这可能与妊娠相关的青光眼和角膜扩张性疾病有关。
