5-（α-羟基-链烷酰氨基）-2,4,6-三碘间苯二甲酰胺的分子重排
Molecular rearrangement of 5-(a-hydroxy-alkanoylamino)-2,4,6-triiodo-isophthalic acid amides.
作者信息
Felder E, Gallotti A, Favilla A
机构信息
Bracco Industria Chimica Spa, Milan, Italy.
出版信息
Invest Radiol. 1988 Sep;23 Suppl 1:S101-5. doi: 10.1097/00004424-198809001-00010.
Abstract
Iomeprol, a new nonionic contrast agent, undergoes in alkaline solution a Smiles-type intramolecular rearrangement to give 5-methylaminocarbonylmethoxy-2,4,6-triiodoisophthalic acid-bis-(2,3-dihydroxypropylamide). The rearranged product was isolated and its structure confirmed by spectra and by synthesis. The reaction is reversible and could be extended to some structurally related compounds.
摘要
碘美普尔，一种新型非离子型造影剂，在碱性溶液中会发生史密尔斯型分子内重排反应，生成5-甲基氨基甲酰基甲氧基-2,4,6-三碘间苯二甲酸-双-(2,3-二羟基丙酰胺)。分离出重排产物，并通过光谱和合成对其结构进行了确认。该反应是可逆的，并且可以扩展到一些结构相关的化合物。
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