Morris T W, Ekholm S E, Simon J H, Marinetti G V, Harnish P P, Isaac L, Fonte D, Leakey P
Department of Diagnostic Radiology, University of Rochester Medical Center, NY 14642.
Invest Radiol. 1988 Sep;23 Suppl 1:S213-6. doi: 10.1097/00004424-198809001-00043.
Water-soluble nonionic x-ray contrast media have greatly improved the quality and safety of myelography. Toxic side effects are still observed however. The side effects are generally worse with the first nonionic agent, metrizamide, which has a glucoselike side group. Two in vitro models were developed to examine the effects of contrast media on glucose metabolism. Using rat hippocampus slices, the authors observed significant depression of carbon dioxide production by metrizamide and by deoxyglucose, a known metabolic inhibitor. Iohexol and iopamidol did not cause significant depressions. In rat brain synaptosomes the authors did not observe a depression of the uptake of deoxyglucose 14C by any media tested. These studies indicate that metrizamide can create metabolic depression but that it does not compete with glucose for the membrane glucose carrier.
水溶性非离子型X射线造影剂极大地提高了脊髓造影的质量和安全性。然而，仍可观察到毒性副作用。第一种非离子型造影剂甲泛葡胺具有类似葡萄糖的侧链基团，其副作用通常更严重。我们建立了两种体外模型来研究造影剂对葡萄糖代谢的影响。作者利用大鼠海马切片观察到，甲泛葡胺和已知的代谢抑制剂脱氧葡萄糖均显著抑制二氧化碳生成。碘海醇和碘帕醇未引起显著抑制。在大鼠脑突触体中，作者未观察到任何受试造影剂抑制14C-脱氧葡萄糖的摄取。这些研究表明，甲泛葡胺可导致代谢抑制，但它并不与葡萄糖竞争膜葡萄糖载体。
