Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.
Department of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
J Clin Neurosci. 2020 Apr;74:240-241. doi: 10.1016/j.jocn.2020.01.055. Epub 2020 Jan 23.
Immune checkpoint inhibitors, also known as immunotherapy, have revolutionised the treatment of metastatic melanoma, but are frequently associated with immune-related adverse events (irAEs) affecting a variety of organ systems. Here, we present a case of a patient with metastatic melanoma, being treated with combination ipilimumab-nivolumab, who developed a foot drop. MRI demonstrated enhancement of the nerve roots of the cauda equina. The patient had other irAEs, which warranted cessation of immunotherapy and the introduction of corticosteroids, and this also resulted in improvement in the patient's lower limb symptoms and MRI appearances. This confirmed an autoimmune polyradiculitis - a rare irAE.
免疫检查点抑制剂，也称为免疫疗法，已经彻底改变了转移性黑色素瘤的治疗方法，但经常与影响多种器官系统的免疫相关不良事件（irAE）相关。在这里，我们介绍了一位接受 ipilimumab-nivolumab 联合治疗的转移性黑色素瘤患者的病例，该患者出现足下垂。MRI 显示马尾神经根增强。该患者还有其他 irAE，需要停止免疫治疗并引入皮质类固醇，这也导致患者下肢症状和 MRI 表现的改善。这证实了一种自身免疫性多神经根炎 - 一种罕见的 irAE。
